WarioWare: Move It! is, like other installments in the WarioWare series, a party game consisting of various microgames with distinct art-styles. Being a successor to WarioWare: Smooth Moves, its gameplay utilizes motion controls, with the Joy-Con (referred to in-game as the Form Stones) as controllers. Unlike previous installments in the series, which primarily take place in Diamond City, the game takes place on a new tropical location, named Caresaway Island. As such, the characters of the game wear tropical outfits. The cutscenes of the game make use of full-motion video animation with full voice-acting, like WarioWare Gold.

In the game, the story mode can be played either single- or multiplayer. Its level selection screen is reminiscent of WarioWare: Smooth Moves and WarioWare: Get It Together!; each level is represented by one to three character heads, while the remix stages are represented by jeepneys that hold select characters. Story multiplayer returns from Get It Together! with slight differences. Players take turns playing single-player microgames, and if one player fails, the second player can preserve the life at stake in a tag-in challenge by playing the same microgame. If the second player fails the tag-in, the life is lost. Ocassionally, the players will play a two-player microgame simultaneously and must complete the microgame together.

The party mode of the game features five multiplayer modes (two returning from WarioWare, Inc.: Mega Party Game$!) which can be played with up to four players, who each choose a crew member to play as